用于测定人血浆中马普替林和奥沙普替林的定量高效液相色谱法。
Quantitative high-performance liquid chromatographic assay for the determination of maprotiline and oxaprotiline in human plasma.
作者信息
Kuss H J, Feistenauer E
出版信息
J Chromatogr. 1981 Jan 16;204:349-53. doi: 10.1016/s0021-9673(00)81678-7.
PMID:7217264
Abstract
A procedure is described which permits the determination of maprotiline and oxaprotiline in human blood or plasma at therapeutic concentrations. The biological fluids are extracted with base and the extract is injected into a high-performance liquid chromatograph. The substances are detected by a UV detector operating at 214 nm, amitriptyline being used as internal standard. Concentrations as low as 2 ng per sample can be measured.
摘要
本文描述了一种可测定人血液或血浆中治疗浓度的马普替林和奥沙普替林的方法。生物流体用碱萃取，萃取液注入高效液相色谱仪。通过在214nm波长下操作的紫外检测器检测这些物质，以阿米替林作为内标。每个样品可检测低至2ng的浓度。
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