Park G D, Spector R, Goldberg M J, Johnson G F, Feldman R, Quee C K
J Clin Pharmacol. 1984 Jul;24(7):289-92. doi: 10.1002/j.1552-4604.1984.tb01835.x.
The effect of the surface area of activated charcoal on theophylline clearance was studied. Eight fasting, healthy men received intravenous infusions of either aminophylline (6 mg/kg, N = 3) or theophylline (5 mg/kg, N = 5) over 1 hour followed by either 5 Gm standard activated charcoal every 2 hours, 20 Gm every 2 hours, or 5 Gm PX-21 activated charcoal (with 3.6 times the surface area) every 2 hours. Theophylline t 1/2 and AUC with each regimen were respectively 6.3 +/- 0.5 (S.E.) hours and 88.9 +/- 8.4 mg/liter X hr with 5 Gm standard activated charcoal, 5.3 +/- 0.3 hours and 75.4 +/- 4.9 mg/liter X hr with 5 Gm PX-21, and 4.9 +/- 0.2 hours and 67.7 +/- 3.6 mg/liter X hr with 20 Gm standard activated charcoal. There was a relationship between the activated charcoal surface area and the reduction in theophylline t 1/2 and AUC. We conclude that the clearance of theophylline is related to the surface area of activated charcoal administered and that PX-21 may be a more potent activated charcoal product for enhancing theophylline removal.
研究了活性炭表面积对茶碱清除率的影响。8名空腹健康男性在1小时内静脉输注氨茶碱（6mg/kg，N = 3）或茶碱（5mg/kg，N = 5），随后每2小时分别给予5g标准活性炭、每2小时给予20g标准活性炭或每2小时给予5g PX - 21活性炭（表面积为标准活性炭的3.6倍）。每种给药方案下茶碱的半衰期（t1/2）和药时曲线下面积（AUC）分别为：5g标准活性炭组，6.3±0.5（标准误）小时和88.9±8.4mg/升·小时；5g PX - 21活性炭组，5.3±0.3小时和75.4±4.9mg/升·小时；20g标准活性炭组，4.9±0.2小时和67.7±3.6mg/升·小时。活性炭表面积与茶碱t1/2及AUC的降低之间存在关联。我们得出结论，茶碱的清除率与所给予活性炭的表面积有关，并且PX - 21可能是一种更有效的用于增强茶碱清除的活性炭产品。
