Muravskaia G V, Furmanchuk A V, Fastovskiĭ V L, Pantiushenko T A
Med Radiol (Mosk). 1984 Sep;29(9):39-42.
The long-term results of the combined therapy of 284 patients with infiltrative forms of breast cancer were correlated with the manifestations of radiation pathomorphosis in a tumor after preoperative radiation therapy at a single dose of 4 Gy, summary dose of 20 Gy. Surgical intervention was performed in 59% of the patients in the first 3 days after irradiation, in 30% of the patients in 4-9 days, in 11% in 10-20 days. The degree of radiation pathomorphosis was evaluated by the signs of disturbance of the general structure of the tumorous tissue and the structure of some cancer cells. The most significant changes in tumors were recorded 10-20 days after the termination of radiation therapy. An increase in the interval between the termination of irradiation and operation up to 20 days did not influence the long-term results of the combined therapy of patients with breast cancer. No correlation between the degree of radiation pathomorphosis and long-term results of combined therapy was revealed, therefore the qualitative determination of the degree of injury of tissue and cellular elements of a tumor cannot serve as an adequate criterion of efficacy of mean fractional radiation exposure in performing operation in the first 9 days after its completion.
对284例浸润性乳腺癌患者采用单一剂量4Gy、总剂量20Gy的术前放疗，之后联合治疗的长期结果与放疗后肿瘤的放射病理形态学表现相关。59%的患者在放疗后前3天接受手术干预，30%的患者在4 - 9天接受手术，11%的患者在10 - 20天接受手术。通过肿瘤组织总体结构及部分癌细胞结构紊乱的征象评估放射病理形态学程度。放疗结束后10 - 20天记录到肿瘤最显著的变化。将放疗结束至手术的间隔延长至20天对乳腺癌患者联合治疗的长期结果无影响。未发现放射病理形态学程度与联合治疗长期结果之间存在相关性，因此，在放疗结束后前9天进行手术时，对肿瘤组织和细胞成分损伤程度的定性测定不能作为平均分次放疗疗效的充分标准。
