Firsova P P, Kuznetsova R A
Med Radiol (Mosk). 1984 Mar;29(3):20-4.
The therapeutic, social and economic aspects of the efficacy of intense preoperative irradiation in combined therapy of breast cancer were analysed. It has been established that preoperative irradiation in the form of the fractionation of a single focal dose of 6 Gy every other day, the summary dose of 24 Gy within 8-10 days followed by surgery 1-3 days after irradiation does not either complicate its performance or the course of the postoperative period, and by the short- and long-term results it is no worse than the routine dose fractionation. Large dose fractionation saves the time of preoperative irradiation (10 days instead of 5-6 weeks), reduces the time of inpatients' stay (56-70 days instead of 90-100 days), enables most of the patients after treatment to resume work 1.2-2 mos. earlier than after the routine dose fractionation. Preoperative irradiation in the form of large dose fractionation reduces the time of treatment, does not change its efficacy and provides for a greater economic effect.
分析了术前大剂量分割照射在乳腺癌综合治疗中的疗效、社会和经济方面。已确定，以每隔一天单次局部剂量6Gy进行分割，在8 - 10天内总剂量达24Gy，然后在照射后1 - 3天进行手术的术前照射，既不会使手术操作或术后病程复杂化，且就短期和长期结果而言，并不比常规剂量分割差。大剂量分割节省了术前照射时间（10天而非5 - 6周），减少了住院时间（56 - 70天而非90 - 100天），使大多数接受治疗后的患者能够比常规剂量分割后提前1.2 - 2个月恢复工作。大剂量分割形式的术前照射缩短了治疗时间，不改变疗效，并产生了更大的经济效益。
