Ray J H
Mutat Res. 1984 Sep;141(1):49-53. doi: 10.1016/0165-7992(84)90037-x.
Sodium selenite (Na2SeO3) is an anticarcinogenic/antimutagenic agent that exhibits carcinogenic/mutagenic properties in some short-term test systems used for the detection of DNA-damaging agents. One such test system is sister-chromatid exchange (SCE) induction. Na2SeO3 induces SCEs only if red blood cells (RBCs) are present to 'activate' it to its SCE-inducing form. Here, the ability of reduced glutathione, a major component of RBCs, to serve as an RBC substitute in the activation of Na2SeO3 was determined. Reduced glutathione (10(-4) and 10(-3) M) was shown to be as capable as RBCs in activating Na2SeO3 (7.95 X 10(-6) M) to its SCE-inducing form. These data suggest strongly that the pathway normally utilized by RBCs in the metabolism of Na2SeO3 is the same as that in which Na2SeO3 is converted to its SCE-inducing form.
亚硒酸钠（Na2SeO3）是一种抗癌/抗诱变剂，但在一些用于检测DNA损伤剂的短期测试系统中，它却表现出致癌/诱变特性。姐妹染色单体交换（SCE）诱导试验就是这样一种测试系统。只有当存在红细胞（RBC）将其“激活”为SCE诱导形式时，Na2SeO3才会诱导SCE。在此，研究了红细胞的主要成分还原型谷胱甘肽作为红细胞替代物在激活Na2SeO3中的能力。结果表明，还原型谷胱甘肽（10^(-4)和10^(-3) M）在将Na2SeO3（7.95×10^(-6) M）激活为SCE诱导形式方面与红细胞能力相当。这些数据有力地表明，红细胞在Na2SeO3代谢中正常利用的途径与Na2SeO3转化为SCE诱导形式的途径相同。
