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中央脊髓损伤管理的再分析

Reanalysis of central cervical cord injury management.

作者信息

Bose B, Northrup B E, Osterholm J L, Cotler J M, DiTunno J F

出版信息

Neurosurgery. 1984 Sep;15(3):367-72. doi: 10.1227/00006123-198409000-00012.

Abstract

Early investigators indicated that conservative management was superior to operative intervention in the treatment of central cord injuries. Their clinical data suggested that operative treatment, in fact, worsened the condition. Recent experience with this clinical entity, however, indicates that in selected patients operative intervention may be of value in improving the rate and degree of motor recovery. A retrospective study of all individuals admitted to our hospital (Delaware Valley Spinal Cord Injury Center) with central cervical spinal cord injury was done (28 patients). One-half had been treated with medical therapy alone (Group I); the others were treated both medically and surgically (Group II). Medical therapy consisted of intravenous mannitol, dexamethasone, and sodium bicarbonate given during the acute phase of the injury. Both groups were immobilized using either a halo or a Philadelphia collar. Criteria for entry into the surgical group were one or both of the following: (a) failure to improve progressively after an initial period of improvement, with persistent compression of neural tissue visualized on myelography and (b) unacceptable instability of the spinal bony elements. The patients were given neurological scores based on the motor power of the major muscle groups. The stability of the spine was scored using the Panjabi-White scale. The two groups were compared using Student's t-test and the two-factor analysis of variance. There was no significant difference in initial neurological scores between the groups. The surgical groups had a higher incidence of instability of the bony elements of the cervical spine, as judged by the Panjabi-White scale.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

早期研究者指出,在中央脊髓损伤的治疗中,保守治疗优于手术干预。他们的临床数据表明,实际上手术治疗会使病情恶化。然而,近期针对这一临床病症的经验表明,对于部分患者,手术干预可能有助于提高运动恢复的速度和程度。我们对所有入住我院(特拉华谷脊髓损伤中心)的中央型颈脊髓损伤患者进行了一项回顾性研究(共28例患者)。其中一半仅接受了药物治疗(第一组);另一半则同时接受了药物和手术治疗(第二组)。药物治疗包括在损伤急性期静脉输注甘露醇、地塞米松和碳酸氢钠。两组患者均使用头环或费城颈托进行固定。纳入手术组的标准为以下一项或两项:(a)在最初一段时间有所改善后未能持续改善,脊髓造影显示神经组织持续受压,以及(b)脊柱骨结构存在不可接受的不稳定。根据主要肌肉群的运动能力对患者进行神经学评分。使用潘贾比 - 怀特量表对脊柱稳定性进行评分。采用学生t检验和双因素方差分析对两组进行比较。两组患者的初始神经学评分无显著差异。根据潘贾比 - 怀特量表判断,手术组颈椎骨结构不稳定的发生率更高。(摘要截断于250字)

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