Nielsen J A, Sparber S B
Pharmacol Biochem Behav. 1984 Aug;21(2):219-24. doi: 10.1016/0091-3057(84)90218-1.
Prostaglandins (PGs) may be important in modulating the actions of d-amphetamine. To test this hypothesis male rats were pretreated with indomethacin to inhibit PG synthesis before d-amphetamine was injected. Indomethacin (5 mg/kg, IP) was found to be without direct effect upon fixed-ratio behavior or rectal temperature, but significantly enhanced the capacity of low doses of d-amphetamine to suppress behavior and lower temperature. These effects were not due to partial food deprivation or to an increase in the concentration of d-amphetamine in brain. It is concluded that one or more of the PGs modulate the central actions of d-amphetamine, perhaps by modifying the release and/or reuptake of catecholamines, or through a postsynaptic action.
前列腺素（PGs）可能在调节右旋苯丙胺的作用中起重要作用。为了验证这一假设，在注射右旋苯丙胺之前，先给雄性大鼠注射消炎痛以抑制PG合成。发现消炎痛（5毫克/千克，腹腔注射）对固定比率行为或直肠温度无直接影响，但能显著增强低剂量右旋苯丙胺抑制行为和降低体温的能力。这些作用并非由于部分食物剥夺或脑内右旋苯丙胺浓度增加所致。得出的结论是，一种或多种PGs可能通过改变儿茶酚胺的释放和/或再摄取，或通过突触后作用来调节右旋苯丙胺的中枢作用。
