Peterson D W, Sparber S B
Pharmacol Biochem Behav. 1976 May;4(5):545-9. doi: 10.1016/0091-3057(76)90196-9.
Approximately equieffective doses of d- and l-amphetamine, using suppression of operant fixed-ratio responding for food reinforcement as the determinant of potency, were compared for their ability to alter the disposition of the major and minor metabolites of NE in push-pull perfusates from rat brain lateral ventricle. While 3 mg d-amphetamine/kg and 6 mg l-amphetamine/kg both increased total 3H and the relative amounts of the minor metabolites 3H-normetanephrine and 3H-dihydroxymandelic acid, only 1-amphetamine caused a significant increase in the major 3H-NE metabolite, methoxyhydroxyphenylethylene-glycol. The data is discussed in relation to the abilities of the isomers of amphetamine to stereoselectively interact with noradrenergic neurons at doses that produce similar effects upon operant behavior.
以抑制操作性固定比率食物强化反应作为效力的决定因素，比较了等量效应剂量的右旋和左旋苯丙胺改变大鼠脑侧脑室推挽灌注液中去甲肾上腺素（NE）主要和次要代谢产物分布的能力。虽然3mg/kg的右旋苯丙胺和6mg/kg的左旋苯丙胺均增加了总3H以及次要代谢产物3H-去甲间羟肾上腺素和3H-二羟扁桃酸的相对量，但只有左旋苯丙胺使主要的3H-NE代谢产物甲氧基羟基苯乙二醇显著增加。结合苯丙胺异构体在对操作性行为产生相似效应的剂量下与去甲肾上腺素能神经元立体选择性相互作用的能力对数据进行了讨论。
