Schmitt P, Karli P
Physiol Behav. 1984 Apr;32(4):617-27. doi: 10.1016/0031-9384(84)90317-2.
Interactions between aversive and rewarding effects of brain stimulations were studied by assessing the variation of both escape and approach responses induced in a shuttle box by applying electrical stimulations of various intensities simultaneously to a medial hypothalamic (MH) site and to a lateral hypothalamic (LH) site. The results obtained show that: (1) LH stimulation produces two effects whose relative strengths appear to depend on both the location of the stimulation site and the intensity applied: (a) a suppressant effect correlated with the rewarding effect, which reduces MH escape responding; and (b) an enhancing effect correlated with the aversive effect, which increases MH escape responding. (2) MH stimulation similarly produces two effects whose relative strengths vary with both the location of the stimulation site and the intensity applied: (a) an enhancing effect which increases LH approach responding and (b) a suppressant effect which decreases LH approach responding. (3) The above-mentioned effects occur irrespective of whether the two stimulation sites (MH and LH) are ipsi- or contralateral to each other. These results suggest that the effects of LH stimulation on MH induced escape as well as those of MH stimulation on LH induced approach are related to the affective (aversive, rewarding) properties of the stimulation.
通过评估在穿梭箱中同时对内侧下丘脑（MH）部位和外侧下丘脑（LH）部位施加不同强度电刺激所诱发的逃避反应和趋近反应的变化，研究了脑刺激的厌恶效应和奖赏效应之间的相互作用。所得结果表明：（1）LH刺激产生两种效应，其相对强度似乎取决于刺激部位的位置和所施加的强度：（a）一种与奖赏效应相关的抑制效应，可降低MH逃避反应；（b）一种与厌恶效应相关的增强效应，可增加MH逃避反应。（2）MH刺激同样产生两种效应，其相对强度随刺激部位的位置和所施加的强度而变化：（a）一种增强效应，可增加LH趋近反应；（b）一种抑制效应，可降低LH趋近反应。（3）上述效应的出现与两个刺激部位（MH和LH）是同侧还是对侧无关。这些结果表明，LH刺激对MH诱发逃避的影响以及MH刺激对LH诱发趋近的影响与刺激的情感（厌恶、奖赏）特性有关。
