Sandner G, Schmitt P, Karli P
Physiol Behav. 1985 Feb;34(2):291-7. doi: 10.1016/0031-9384(85)90118-0.
The effects of unilateral--medial or lateral--hypothalamic lesions were studied with regard to both switch-off (i.e., escape) responding induced by central gray (CG) stimulation and responsiveness of the same animals to peripherally-applied electrical or thermal stimulation. Medial hypothalamic (MH) lesions were found to reduce--but not abolish--the efficiency of CG stimulations applied on the side of the MH lesion, while the efficiency of contralaterally applied CG stimulations remained unchanged. Furthermore, such lesions enhanced the responsiveness to peripheral nociceptive stimuli on whatever body side they were applied. Lateral hypothalamic lesions were found to only slightly--or not at all--affect the efficiency of CG stimulations, while they enhanced the responsiveness to peripheral nociceptive stimuli on either side of the body. These results suggest that the hypothalamus does not exert a univocal control over both centrally induced escape behavior and peripherally induced withdrawal reactions.
研究了单侧（内侧或外侧）下丘脑损伤对由中脑导水管周围灰质（CG）刺激诱发的“关闭”（即逃避）反应以及同一动物对外周施加的电刺激或热刺激的反应性的影响。发现内侧下丘脑（MH）损伤会降低（但不会消除）在MH损伤侧施加的CG刺激的效率，而对侧施加的CG刺激的效率保持不变。此外，此类损伤增强了动物对无论施加于身体哪一侧的外周伤害性刺激的反应性。发现外侧下丘脑损伤仅轻微影响或根本不影响CG刺激的效率，而它们增强了动物对身体两侧外周伤害性刺激的反应性。这些结果表明，下丘脑对中枢诱导的逃避行为和外周诱导的退缩反应并非发挥单一的控制作用。
