从动物实验推断人类的致癌风险。
Extrapolation of carcinogenic risk from animal experiments in man.
作者信息
Ehrenberg L, Holmberg B
出版信息
Environ Health Perspect. 1978 Feb;22:33-5. doi: 10.1289/ehp.782233.
When estimating the absolute risk of cancer, the shape of the dose--response curve in the region of doses where actual exposure of man occurs is of crucial importance. This shape is equally important for the determination of relative risks, as in the comparison of risks from alternative energy sources. Experimental and epidemiological studies are, for various reasons, unable to give sufficiently exact information concerning the dose response in the low dose region. Therefore, the discussion concerning dose--response relationships also has to consider biologically reasonable mechanisms for the origin of tumors.
在估计癌症的绝对风险时，在人类实际接触剂量范围内剂量反应曲线的形状至关重要。这种形状对于确定相对风险同样重要，比如在比较替代能源的风险时。由于各种原因，实验研究和流行病学研究无法提供关于低剂量区域剂量反应的足够精确信息。因此，关于剂量反应关系的讨论也必须考虑肿瘤发生的生物学合理机制。
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