关于癌症反应从高剂量外推至低剂量的评论
Comments on extrapolation of cancer response from high dose to low dose.
作者信息
Nelson N
出版信息
Environ Health Perspect. 1978 Feb;22:93-5. doi: 10.1289/ehp.782293.
Abstract
In making judgments as to the cancer risk from low level exposure to carcinogens it is generally necessary to base these judgments on high dose or high incidence data from laboratory or epidemiological studies. The biological considerations involved in making such extrapolations are discussed, as well as some of the mathematical procedures. The difficulties presented by moving from species to species, or from differently acting carcinogenic agents is considered.
摘要
在判断低水平接触致癌物所带来的癌症风险时，通常有必要依据实验室研究或流行病学研究中的高剂量或高发病率数据来做出这些判断。文中讨论了进行此类推断时涉及的生物学考量因素，以及一些数学方法。还考虑了在不同物种之间或不同作用机制的致癌剂之间进行推断时所面临的困难。
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本文引用的文献
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2
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