Olson L J, Hsia M T, Kreamer B L, Hinsdill R D
Toxicology. 1984 Sep 28;32(4):287-96. doi: 10.1016/0300-483x(84)90081-7.
The acute immunomodulatory effects of the environmental and occupational contaminant, 3,3',4,4'-tetrachloroazoxybenzene (TCAOB), were investigated on selected immune parameters in weanling and adult Sprague-Dawley rats. Significant immunotoxic effects were found 17 days after 4 doses of 25 mg/kg TCAOB, administered i.p. The main non-immune toxic effects were decreased body, kidney, heart and testis weights, and a simultaneous increase in liver weight. The immune parameters showing significant suppression were: thymic weight, splenic plaque forming cell populations and function, pertioneal macrophage chemiluminescence, and bone marrow cellularity. Weanling animals were affected by TCAOB to a greater extent than adults on both the multiple and single dose regimens. The immunotoxic effects were found to be qualitatively similar to those of its isosteric analog, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The results demonstrate that TCAOB is a very potent immunotoxic compound and may have long-term effects after a single exposure. This study is the first investigation into the effect of TCAOB on immune functions.
研究了环境和职业污染物3,3',4,4'-四氯偶氮苯（TCAOB）对断奶和成年Sprague-Dawley大鼠某些免疫参数的急性免疫调节作用。腹腔注射4剂25mg/kg TCAOB后17天发现了显著的免疫毒性作用。主要的非免疫毒性作用包括体重、肾脏、心脏和睾丸重量减轻，同时肝脏重量增加。显示出显著抑制作用的免疫参数有：胸腺重量、脾脏斑块形成细胞数量和功能、腹腔巨噬细胞化学发光以及骨髓细胞性。在多剂量和单剂量方案中，断奶动物比成年动物受TCAOB的影响更大。发现其免疫毒性作用在性质上与其等排类似物2,3,7,8-四氯二苯并对二恶英（TCDD）的作用相似。结果表明，TCAOB是一种非常有效的免疫毒性化合物，单次接触后可能产生长期影响。本研究是对TCAOB对免疫功能影响的首次调查。
