Pfister W, Sprössig M, Gängler P, Mirgorod M
Zentralbl Bakteriol Mikrobiol Hyg A. 1984 Aug;257(3):364-71.
In a time period of 21 days an experimental gingivitis was induced in 8 volunteers. Four volunteers received a carbohydrate-reduced, the other 4 persons a carbohydrate-enriched diet. Clinical investigations on the development of plaque and gingivitis and bacteriological examinations of the supragingival microflora were performed simultaneously. The change in the composition of the supragingival plaque-microflora were nearly independent of the amount of food-carbohydrate. In the beginning of the experiment all volunteers had an almost pure streptococcal microflora but during the course of the experiment, the supragingival flora developed to a complex microflora with 50% anaerobes. The reduction of the number of streptococci was accompanied by an increase in the number of Gram-negative rods and actinomycetes. The development of gingivitis in persons with carbohydrate-enriched food was more rapid than in persons with carbohydrate-reduced food. It was striking that the occurrence of clinical symptoms correlated with the increase of the number of Actinomyces viscosus in the plaque material.
在21天的时间段内，对8名志愿者诱发了实验性牙龈炎。4名志愿者接受低糖饮食，另外4人接受高糖饮食。同时进行了关于菌斑和牙龈炎发展的临床调查以及龈上微生物群的细菌学检查。龈上菌斑微生物群组成的变化几乎与食物碳水化合物的量无关。实验开始时，所有志愿者几乎都有纯链球菌微生物群，但在实验过程中，龈上菌群发展为含有50%厌氧菌的复杂菌群。链球菌数量的减少伴随着革兰氏阴性杆菌和放线菌数量的增加。高糖饮食者牙龈炎的发展比低糖饮食者更快。值得注意的是，临床症状的出现与菌斑材料中粘性放线菌数量的增加相关。
