Smorodintsev A A
Zh Mikrobiol Epidemiol Immunobiol. 1984 Jul(7):33-7.
The advantages of live attenuated vaccines over inactivated vaccines in the prophylaxis of some viral infections are shown: attenuated vaccines, apart from their ability to stimulate systemic humoral immunity, are capable of the mobilization of cytotoxic killer reactions with the participation of T lymphocytes and macrophages, the stimulation of local secretory immunity and long-term immunological memory. The organizational drawbacks of the modern vaccinal prophylaxis of influenza and measles with the use of live vaccines manufactured in the USSR are analyzed and effective ways for the elimination of these drawbacks are proposed.
减毒疫苗除了能够刺激全身体液免疫外,还能够在T淋巴细胞和巨噬细胞的参与下激发细胞毒性杀伤反应,刺激局部分泌免疫和长期免疫记忆。分析了苏联生产的流感和麻疹活疫苗在现代疫苗预防中的组织缺陷,并提出了消除这些缺陷的有效方法。