Shigematsu H, Murakami S, Akikusa B
Acta Pathol Jpn. 1984 Jul;34(4):715-26. doi: 10.1111/j.1440-1827.1984.tb07600.x.
The extratubular efflux of periodic acid-Schiff (PAS) positive material is used as a histological indicator of intrarenal reflux, and correlation of the PAS positive material and interstitial as well as glomerular changes were analyzed in 114 surgical specimens consisting of renal calculi, hydronephrosis, vesicoureteral reflux, and others. (1) The incidence of extratubular efflux was apparently higher in the kidneys of hydronephrosis. (2) PAS positive material was seen not only in the interstitium but also flowed into the venous and lymphatic spaces. (3) Potent interstitial mononuclear cell infiltration and larger amounts of PAS positive material were seen in the kidneys showing a moderate grade of hydronephrosis rather than renal calculi. (4) Global glomerular sclerosis was the most frequent glomerular lesion, and segmental sclerosis and crescentic epithelial reaction in a small number of glomeruli were also noted. These results imply that intrarenal reflux could play an important role in the development of various renal tissue injuries.
过碘酸-希夫（PAS）阳性物质的肾小管外溢被用作肾内反流的组织学指标，并在114例包括肾结石、肾积水、膀胱输尿管反流等的手术标本中分析了PAS阳性物质与间质以及肾小球变化的相关性。（1）肾积水患者肾脏中肾小管外溢的发生率明显更高。（2）PAS阳性物质不仅见于间质，还流入静脉和淋巴管间隙。（3）在中度肾积水的肾脏中可见强烈的间质单核细胞浸润和大量PAS阳性物质，而非肾结石患者。（4）弥漫性肾小球硬化是最常见的肾小球病变，少数肾小球还可见节段性硬化和新月形上皮反应。这些结果表明肾内反流可能在各种肾组织损伤的发生发展中起重要作用。
