Shigematsu H, Murakami S
Department of Pathology, Shinshu University School of Medicine, Japan.
Nihon Jinzo Gakkai Shi. 1990 Mar;32(3):331-7.
Using anti-Tamm-Horsfall protein (THP) immunohistochemical study was performed to analyse the relationship between intrarenal reflux and induced nephropathy in surgically resected kidney tissues including hydronephrosis, renal calculi and trauma. With the increase of the histological grade of hydronephrosis intrarenal reflux was observed in two ways. Extra-tubular efflux of THP was seen to correlate with mononuclear and lymphocytic interstitial inflammation with the initiation by cellular immune response. The reflux of THP was also observed in the Bowman's space, but this did not seem to result in glomerular lesions including adhesion and/or sclerosis.
利用抗Tamm-Horsfall蛋白（THP）免疫组织化学研究，对手术切除的肾组织（包括肾积水、肾结石和创伤）中肾内反流与诱发肾病之间的关系进行分析。随着肾积水组织学分级的增加，以两种方式观察到肾内反流。可见THP的肾小管外流出与细胞免疫反应引发的单核细胞和淋巴细胞间质性炎症相关。在鲍曼间隙也观察到THP反流，但这似乎并未导致包括粘连和/或硬化在内的肾小球病变。
