Rollag A, Jacobsen C D
Acta Med Scand. 1984;216(1):105-9. doi: 10.1111/j.0954-6820.1984.tb03778.x.
In 1976, 121 patients with benign gastric ulcer and 13 with gastric carcinoma were diagnosed in our department by endoscopy, cytology and directed biopsies. At a 5-year follow-up, 78 of these patients were re-examined with endoscopy and biopsies. None had developed gastric cancer during the observation time. Of the 78 patients who underwent endoscopy, 16 had gastric ulcer, 2 duodenal ulcer and 27 atrophic gastritis, including 3 with moderate dysplasia of the gastric mucosa. The patients with ulcer had remarkably few symptoms. Only few data are available concerning the postulated link between gastric ulcer disease and gastric malignancy. The cancer-ex-ulcere hypothesis seems to be a medical dogma. However, well planned prospective studies with endoscopic follow-up of gastric ulcers are needed to elucidate the question properly.
1976年，我科通过内镜检查、细胞学检查和定向活检诊断出121例良性胃溃疡患者和13例胃癌患者。在5年的随访中，对其中78例患者进行了内镜检查和活检复查。在观察期内，无一例发生胃癌。在接受内镜检查的78例患者中，16例患有胃溃疡，2例患有十二指肠溃疡，27例患有萎缩性胃炎，其中3例胃黏膜有中度发育异常。溃疡患者的症状明显较少。关于胃溃疡疾病与胃癌之间假定联系的可用数据很少。癌性溃疡假说似乎是一种医学教条。然而，需要精心设计的前瞻性研究，对胃溃疡进行内镜随访，以恰当地阐明这个问题。
