Nilsson C, Sterner G, Idvall J
Acta Med Scand. 1984;216(1):137-40. doi: 10.1111/j.0954-6820.1984.tb03783.x.
A case of severe carbamazepine intoxication (total dose 80 g) is reported. Because of deep coma and cardiovascular symptoms, intensive care and hemoperfusion were employed. The carbamazepine hemoperfusion clearance rate was 80-90 ml/min, but due to a probable ongoing absorption from the gut the effect of hemoperfusion was limited. Long hemoperfusion periods are recommended due to the pharmacokinetic pattern of carbamazepine.
报告了一例严重卡马西平中毒病例（总剂量80克）。由于深度昏迷和心血管症状，采用了重症监护和血液灌流治疗。卡马西平血液灌流清除率为80 - 90毫升/分钟，但由于可能存在肠道持续吸收，血液灌流的效果有限。鉴于卡马西平的药代动力学模式，建议进行长时间的血液灌流。
