可乐定对大鼠肾素释放的抑制机制。

Mechanism of inhibition of renin release by clonidine in rats.

作者信息

Chevillard C, Pasquier R, Duchene N, Alexandre J M

出版信息

Eur J Pharmacol. 1978 Apr 15;48(4):451-4. doi: 10.1016/0014-2999(78)90174-7.

Abstract

In anaesthetized rats, the intracisternal injection of clonidine (1 microgram/kg) reduced mean arterial pressure (MAP), increased plasma renin concentration (PRC) while naphazoline (5 microgram/kg) was ineffective. The i.v. administration of clonidine (30 microgram/kg) still lowered MAP, but in this case, the drug decrease PRC, naphazoline (45 microgram/kg, i.v.) also reduced PRC. It is suggested that i.v. clonidine and naphazoline reduce renin release through activation of alpha-adrenoceptors within the kidney.

摘要

在麻醉大鼠中，脑池内注射可乐定（1微克/千克）可降低平均动脉压（MAP），增加血浆肾素浓度（PRC），而萘甲唑啉（5微克/千克）则无效。静脉注射可乐定（30微克/千克）仍可降低MAP，但在这种情况下，该药物会降低PRC，萘甲唑啉（45微克/千克，静脉注射）也会降低PRC。提示静脉注射可乐定和萘甲唑啉可通过激活肾内的α-肾上腺素能受体来减少肾素释放。