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伯基特淋巴瘤与爱泼斯坦-巴尔病毒围产期感染有关吗?

Is Burkitt's lymphoma related to perinatal infection by Epstein-Barr virus?

作者信息

de-The G

出版信息

Lancet. 1977 Feb 12;1(8007):335-8. doi: 10.1016/s0140-6736(77)91137-0.

Abstract

Burkitt's lymphoma (B.L.) is very restricted geographically, whereas the Epstein-Barr virus (E.B.V.), a very likely causal factor, exists all over the world. It is proposed that perinatal infection (either transplacental, or, more probably, neonatal) is an important risk factor for the development of B.L. This hypothesis arose when the epidemiological characteristics of E.B.V. infection were compared in different parts of the world and is supported by the preliminary results of a seroepidemiological prospective study of B.L. E.B.V. would behave in a manner similar to that of animal tumour viruses whose oncogenic potential is greatly enhanced by neonatal infection.

摘要

伯基特淋巴瘤(B.L.)在地理分布上非常局限,而爱泼斯坦 - 巴尔病毒(E.B.V.)作为一个很可能的致病因素却遍布全球。有人提出围产期感染(要么经胎盘感染,或者更有可能是新生儿期感染)是B.L.发病的一个重要危险因素。当对世界不同地区E.B.V.感染的流行病学特征进行比较时产生了这一假说,并且一项关于B.L.的血清流行病学前瞻性研究的初步结果也支持这一假说。E.B.V.的行为方式可能类似于动物肿瘤病毒,其致癌潜力会因新生儿感染而大大增强。

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