来自乌干达前瞻性研究的关于爱泼斯坦-巴尔病毒与伯基特淋巴瘤之间因果关系的流行病学证据。
Epidemiological evidence for causal relationship between Epstein-Barr virus and Burkitt's lymphoma from Ugandan prospective study.
作者信息
de-Thé G, Geser A, Day N E, Tukei P M, Williams E H, Beri D P, Smith P G, Dean A G, Bronkamm G W, Feorino P, Henle W
出版信息
Nature. 1978 Aug 24;274(5673):756-61. doi: 10.1038/274756a0.
DOI:10.1038/274756a0
PMID:210392
Abstract
Results from a prospective sero-epidemiological study initiated in Uganda in 1971 indicate that children with high antibody titres to Epstein-Barr virus structural antigens are at high risk of developing Burkitt's lymphoma. These findings strongly support a causal relationship between the Epstein-Barr virus and Burkitt's lymphoma but suggest that the oncogenic potential of the virus is realised only in exceptional circumstances.
摘要
1971年在乌干达启动的一项前瞻性血清流行病学研究结果表明，对爱泼斯坦-巴尔病毒结构抗原有高抗体滴度的儿童患伯基特淋巴瘤的风险很高。这些发现有力地支持了爱泼斯坦-巴尔病毒与伯基特淋巴瘤之间的因果关系，但表明该病毒的致癌潜力仅在特殊情况下才会显现。
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