Soper J T, McCarty K S, Hinshaw W, Creasman W T, McCarty K S, Clarke-Pearson D L
Am J Obstet Gynecol. 1984 Oct 15;150(4):342-8. doi: 10.1016/s0002-9378(84)80135-0.
Analyses of cytoplasmic estrogen receptor and progesterone receptor were performed on tumor specimens from 32 patients with uterine sarcomas. While the median and maximal quantitative levels of binding were lower than those observed in endometrial carcinomas, examples of estrogen receptor- and progesterone receptor-positive as well as estrogen receptor- and progesterone receptor-negative tumors were observed in all histologic categories of sarcomas. The presence of significant levels of estrogen receptor binding correlated (p less than 0.05) with the presence of progesterone receptor. The receptor binding status did not correlate with the histologic type of sarcoma, clinical stage, primary or metastatic tumor, presence of extrauterine metastases, age, previous exogenous estrogen therapy, mitotic count, or overall differentiation or nuclear differentiation of the sarcoma. The overall and nuclear differentiation of the carcinomatous elements of homologous mixed müllerian tumors did not correlate with receptor status. The presence of significant levels of estrogen receptor did demonstrate a trend (p less than 0.10) favoring enhanced survival through short-term follow-up, but this trend was not demonstrated with survival beyond 36 months. Steroid receptor status did not otherwise affect prognosis or disease-free survival. No correlation between receptor content and response to hormonal therapy or chemotherapy was observed.
对32例子宫肉瘤患者的肿瘤标本进行了细胞质雌激素受体和孕激素受体分析。虽然结合的中位数和最大定量水平低于子宫内膜癌中的观察值，但在所有组织学类型的肉瘤中均观察到雌激素受体和孕激素受体阳性以及雌激素受体和孕激素受体阴性肿瘤的例子。雌激素受体结合的显著水平与孕激素受体的存在相关（p<0.05）。受体结合状态与肉瘤的组织学类型、临床分期、原发性或转移性肿瘤、子宫外转移的存在、年龄、既往外源性雌激素治疗、有丝分裂计数或肉瘤的总体分化或核分化均无关。同源性混合苗勒管肿瘤中癌性成分的总体和核分化与受体状态无关。雌激素受体显著水平的存在确实显示出一种趋势（p<0.10），即通过短期随访有利于提高生存率，但在36个月后的生存中未显示出这种趋势。类固醇受体状态在其他方面不影响预后或无病生存期。未观察到受体含量与激素治疗或化疗反应之间的相关性。
