Atkinson D P, Jacobs L A, Weaver A W
Am J Surg. 1984 Oct;148(4):483-8. doi: 10.1016/0002-9610(84)90374-x.
Patients with squamous cell carcinoma adherent to the carotid artery have a very poor prognosis, but some can be salvaged by aggressive surgical resection. Preoperative four vessel arteriography with intracranial views is mandatory to detect coexisting arteriosclerotic disease which may limit collateral perfusion of the ipsilateral cerebral hemisphere. Matas-type occlusive tests performed preoperatively are potentially dangerous and do not provide quantitative information that can be obtained intraoperatively by measuring internal carotid artery stump pressures. If the stump pressure is 50 mm Hg or greater, carotid reconstruction is unnecessary. A stump pressure of less than 50 mm Hg is an indication for reconstruction if the pharynx has not been entered during resection. If mucosal entry will be necessary and the stump pressure is less than 50 mm Hg, resection should not be carried out because of the increased risk of graft complications. Somatosensory evoked potentials predict cerebral tolerance to temporary interruption of flow but do not necessarily predict tolerance to permanent interruption of flow. Autogenous vein is the graft material of choice for reconstruction. In those patients not reconstructed, low-dose heparinization started before operation and continued for 10 days may lessen the likelihood of delayed stroke from embolization of a propagated thrombus in the carotid stump.
伴有颈总动脉粘连的鳞状细胞癌患者预后很差,但有些患者可通过积极的手术切除得以挽救。术前必须进行包括颅内显影的四血管动脉造影,以检测可能限制同侧脑半球侧支灌注的并存动脉硬化疾病。术前进行的马塔斯式闭塞试验存在潜在危险,且无法提供可在术中通过测量颈内动脉残端压力获得的定量信息。如果残端压力为50毫米汞柱或更高,则无需进行颈动脉重建。如果在切除过程中未进入咽部,残端压力低于50毫米汞柱是重建的指征。如果有必要进入黏膜且残端压力低于50毫米汞柱,由于移植并发症风险增加,不应进行切除。体感诱发电位可预测大脑对血流暂时中断的耐受性,但不一定能预测对血流永久中断的耐受性。自体静脉是重建的首选移植材料。对于未进行重建的患者,术前开始并持续10天的低剂量肝素化可能会降低因颈动脉残端传播性血栓栓塞导致延迟性中风的可能性。