Lebedev A A, Dubishchev A V
Fiziol Zh SSSR Im I M Sechenova. 1978 Mar;64(3):342-8.
Single administration of furosemid, etacrine acid and mannitol prior to switching off circulation in the only kidney for 2.5 hrs preserves the renal tissue from ischemic lesion, aids to normalizing the excretory processes on the 2nd--4th days of postischemic period, reduces duration of the oligo--anuric phase in acute renal insufficiency, and raises survival rate in the rats. The above substances are ineffective if administered after cessation of the ischemic period. Etacrin acid and novurit suppress functional activity of isolated mitochondria incubated in hypoxia at 37 degrees. Furosemid and mannitol in these conditions exert no effect. Preliminary administration of furosemid aids to preservation of lumen in proximal tubules of superficial nephrones both during cessation of the renal circulation and in the postischemic period.
在阻断唯一肾脏的血液循环2.5小时之前单次给予呋塞米、依他尼酸和甘露醇，可使肾组织免受缺血性损伤，有助于在缺血后第2至4天使排泄过程恢复正常，缩短急性肾功能不全时少尿-无尿期的持续时间，并提高大鼠的存活率。如果在缺血期停止后给予上述物质则无效。依他尼酸和诺尿酸抑制在37℃缺氧条件下孵育的离体线粒体的功能活性。在这些条件下，呋塞米和甘露醇无作用。预先给予呋塞米有助于在肾循环阻断期间和缺血后时期保持浅表肾单位近端小管的管腔通畅。
