Kakari S, Avgoustatos G, Ferderigos A S, Poulaki E, Sakka P, Karamplianis A, Konstadinidis E, Constantopoulos G
Anticancer Res. 1984 Jul-Oct;4(4-5):313-6.
Total sialic acid (TSA) and lipid-bound sialic acid (LSA) were determined in the cerebrospinal fluid (CSF) from 63 patients with various neurological diseases. Of these, 27 had brain tumors: 20 had glioma, and 7 pituitary adenoma. TSA levels were significantly increased in the CSF of 18 of the 20 glioma patients (p less than 0.001), while in the adenoma patients were indistinguishable from the controls; with a 90 and 0% test sensitivity respectively. Conversely, the LSA concentrations were significantly elevated, both, in the glioma and pituitary adenoma patients (p less than 0.001), with a 68 and 100% test sensitivity respectively. These preliminary data suggest that measurement of TSA and LSA in the CSF should prove useful for the diagnosis of brain tumors and, perhaps, in the follow-up of patients undergoing treatment for brain tumors.
对63例患有各种神经系统疾病患者的脑脊液（CSF）中的总唾液酸（TSA）和脂质结合唾液酸（LSA）进行了测定。其中，27例患有脑肿瘤：20例患有神经胶质瘤，7例患有垂体腺瘤。20例神经胶质瘤患者中有18例的脑脊液中TSA水平显著升高（p<0.001），而腺瘤患者与对照组无差异；检测灵敏度分别为90%和0%。相反，神经胶质瘤和垂体腺瘤患者的LSA浓度均显著升高（p<0.001），检测灵敏度分别为68%和100%。这些初步数据表明，脑脊液中TSA和LSA的测定对于脑肿瘤的诊断以及或许对于脑肿瘤治疗患者的随访应是有用的。
