Nevelsteen A, De Clerck F, Loots W, De Gryse A
Arch Int Pharmacodyn Ther. 1984 Aug;270(2):268-79.
In cats, an acute thrombotic obstruction of the aorta inducing continuous platelet activation, was produced by permanent ligation above the trifurcation, temporary ligation below the caudal mesenteric artery and production of a stasis thrombus in the segment. Before, 5 min, 24 hr and 48 hr after surgery, plethysmographic systolic blood pressure in fore- and hindlegs, and clinical scoring of the hindleg function were performed; at 72 hr, venous occlusion plethysmography for quantification of blood flow was performed and collateral vascular resistance was calculated. Thrombotic occlusion resulted in a loss of adequately functioning collateral circulation as evidence by the changes in both the objective and the clinical parameters. Pre-treatment with ketanserin (1.25 mg/kg i.p. daily) significantly improved the objective circulation parameters blood pressure ratio, blood flow and collateral vascular resistance and restored the clinically scored function of post-thrombotic collateral function. Provided platelet activation contributes to human vascular pathology, a similar mechanism may be involved in the potential effect of ketanserin in man.
在猫身上，通过在主动脉三叉上方进行永久性结扎、在肠系膜后动脉下方进行暂时性结扎以及在该节段产生淤滞性血栓，造成主动脉急性血栓性阻塞，从而诱导血小板持续活化。在手术前、术后5分钟、24小时和48小时，测量前肢和后肢的体积描记法收缩压，并对后肢功能进行临床评分；在72小时时，进行静脉阻塞体积描记法以量化血流量并计算侧支血管阻力。血栓性阻塞导致侧支循环功能丧失，这在客观参数和临床参数的变化中均有体现。酮色林预处理（每日腹腔注射1.25毫克/千克）显著改善了客观循环参数，如血压比值、血流量和侧支血管阻力，并恢复了血栓形成后侧支功能的临床评分功能。如果血小板活化与人类血管病变有关，那么酮色林在人体内的潜在作用可能涉及类似的机制。
