Schaub R G, Meyers K M, Sande R D
J Lab Clin Med. 1977 Oct;90(4):645-53.
The relationship of serotonin to the inhibition of collateral blood flow was investigated. Five cats, in which the aorta contained a 6 microgram injection of serotonin in a closed aortic segment exhibited depressed hindlimb blood flow. The serotonin effects were eliminated in three animals by pretreatment with cinarserin HCl, a serotonin antagonist. The caudal 1.5 cm of the aorta was occluded in 24 cats by a blood clot formed by injection of thromboplastin subsequent to ligation. Eight of these animals were pretreated with cinanserin HCl and exhibited a significant improvement in hindlimb collateral blood flow. Serotonin was reduced in nine of these animals with reserpine/p-CPA treatment, and they exhibited the most significant recovery of all treated animals. Seven of the cats with blood serotonin reduced by decreasing blood platelets showed no improvement in hindlimb blood flow. The results of this study indicate that serotonin is a factor in the inhibition of collateral blood flow which follows arterial thrombosis.
研究了血清素与侧支血流抑制之间的关系。五只猫在封闭的主动脉段中注射了6微克血清素，其主动脉中的血清素导致后肢血流减少。通过用血清素拮抗剂盐酸西那色林预处理，三只动物的血清素作用被消除。在24只猫中，通过在结扎后注射凝血活酶形成血栓，阻塞了主动脉尾端1.5厘米。其中八只动物用盐酸西那色林预处理，后肢侧支血流有显著改善。九只动物用利血平/对氯苯丙氨酸治疗后血清素降低，它们在所有治疗动物中恢复最为显著。七只通过减少血小板使血液血清素降低的猫，后肢血流没有改善。这项研究的结果表明，血清素是动脉血栓形成后侧支血流抑制的一个因素。
