Aminoff M J, Davis S L, Panitch H S
Arch Neurol. 1984 Nov;41(11):1197-202. doi: 10.1001/archneur.1984.04050220095025.
Twelve patients with clinically definite multiple sclerosis were examined both clinically and electrophysiologically at repeated intervals over one year to determine the clinical relevance of data obtained by serial multimodality evoked potential studies. We frequently found a disparity between the clinical and electrophysiologic changes, and also an excessive variability between test sessions of the responses to stimulation of a clinically involved afferent pathway even when the clinical deficit was stable. Our findings indicate that though evoked potential studies may provide information of diagnostic relevance, their role in monitoring disease progression has not been established.
12例临床确诊的多发性硬化症患者在一年时间内接受了多次临床和电生理检查，以确定通过系列多模态诱发电位研究获得的数据的临床相关性。我们经常发现临床和电生理变化之间存在差异，而且即使临床缺陷稳定，对临床受累传入通路刺激的反应在不同测试阶段之间也存在过度的变异性。我们的研究结果表明，虽然诱发电位研究可能提供具有诊断相关性的信息，但它们在监测疾病进展中的作用尚未确立。
