在“宇宙”生物卫星上进行的实验中白鼠的水电解质代谢和肾功能

Fluid-electrolyte metabolism and renal function of white rats in experiments aboard Cosmos biosatellites.

作者信息

Gazenko O G, Ilyushko N A

出版信息

Aviat Space Environ Med. 1984 Aug;55(8):685-91.

Abstract

Rat experiments on the Cosmos biosatellites demonstrated that the percentage of renal excretion of consumed water after flight was lower than after synchronous experiment. This can be attributed not only to water retention but also to a different level of extrarenal losses postflight. Weightless rats showed increased sodium excretion after water load tests and increased potassium excretion after potassium load tests. The sodium, potassium, and calcium balance was positive after weightlessness. Analysis of the electrolyte composition of different kidney zones revealed a decreased potassium content in the medulla, which is considered to be one of the causes of changed renal iono- and osmoregulatory function in weightlessness. The normalizing effect of artificial gravity on the natri- and kaliuretic renal function was demonstrated.

摘要

在宇宙生物卫星上进行的大鼠实验表明，飞行后消耗水分的肾脏排泄百分比低于同步实验后。这不仅可归因于水分潴留，还可归因于飞行后肾外损失的不同水平。失重大鼠在水负荷试验后钠排泄增加，在钾负荷试验后钾排泄增加。失重后钠、钾和钙平衡呈正值。对不同肾区电解质组成的分析显示，髓质中钾含量降低，这被认为是失重状态下肾脏离子和渗透调节功能改变的原因之一。人工重力对肾脏利钠和利尿功能的正常化作用得到了证实。