[慢性氟哌啶醇治疗后大鼠的学习行为]
[Learning behavior in rats after chronic haloperidol treatment].
作者信息
Hoffmann W, Westermann K H
出版信息
Biomed Biochim Acta. 1984;43(4):545-7.
PMID:6487282
Abstract
The effect of 3 week chronic haloperidol treatment has been investigated in rats by retention of active avoidance (pole jumping). In the period of dopaminergic supersensitivity, i.e. after withdrawal of haloperidol, pretreated rats showed a better retention of the learned reaction than controls. The results demonstrate that the neuroleptic-induced supersensitivity enhanced not only the spontaneous and stimulated locomotor activity, but also improved the retention of an active avoidance reaction.
摘要
通过主动回避（跳杆）保持实验，研究了大鼠为期3周的慢性氟哌啶醇治疗效果。在多巴胺能超敏反应期，即氟哌啶醇撤药后，预处理大鼠比对照组对习得反应有更好的保持。结果表明，抗精神病药物引起的超敏反应不仅增强了自发和刺激的运动活性，还改善了主动回避反应的保持。
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