Lober M, Krantz S, Herrmann I
Biomed Biochim Acta. 1984;43(6):835-40.
The immunization of rabbits with a paraoxon-HSA-conjugate resulted in an antibody response with titres of 1:25000 to 1:100000 of antisera dilution and average affinity constants K0 of 10(6) M-1 and heterogeneity indices of 0.8 to 0.9 calculated by means of the Sips equation. The serum cholinesterases and the erythrocyte acetylcholinesterase in immunized rabbits were protected against a stronger inhibition by parenteral application of paraoxon. An increase of blood glucose after paraoxon application to immunized rabbits could not be observed but was detectable in unimmunized animals.
用对氧磷 - 人血清白蛋白偶联物免疫家兔，产生了抗体反应，抗血清稀释度为1:25000至1:100000，通过西普斯方程计算，平均亲和常数K0为10(6) M-1，异质性指数为0.8至0.9。通过肠胃外给予对氧磷，免疫家兔的血清胆碱酯酶和红细胞乙酰胆碱酯酶受到更强的抑制。在免疫家兔中，未观察到给予对氧磷后血糖升高，但在未免疫动物中可检测到。
