Hein R, Krieg T, Mueller P K, Braun-Falco O
Biochem Pharmacol. 1984 Oct 15;33(20):3263-7. doi: 10.1016/0006-2952(84)90088-1.
The effect of vitamin A and of some of its derivatives on chondrocytes in culture has been studied. In the presence of retinoids the proliferation of the cells decreased and they lost their characteristic polygonal shape and assumed a fibroblast-like morphology. All retinoids also caused dedifferentiation of chondrocytes as indicated by the induction of types I and III collagen. 13-cis retinoic acid (= isotretinoin) was the most active derivative in this aspect. Since appropriate control of the synthesis of extracellular matrix proteins is a prerequisite for their normal physiological function, alterations such as those observed here may be involved in the pathogenesis of side effects which are observed during the treatment of dermatological disorders with retinoic acid derivatives.
已经研究了维生素A及其某些衍生物对培养的软骨细胞的影响。在视黄酸存在的情况下，细胞增殖减少，它们失去了特征性的多边形形状，并呈现出成纤维细胞样形态。所有视黄酸还导致软骨细胞去分化，这表现为I型和III型胶原蛋白的诱导。13-顺式视黄酸（=异维甲酸）在这方面是最具活性的衍生物。由于细胞外基质蛋白合成的适当控制是其正常生理功能的先决条件，因此此处观察到的变化可能参与了在用视黄酸衍生物治疗皮肤病期间观察到的副作用的发病机制。
