Kanayama R, Takase S, Matsuda Y, Takada A
Biochem Pharmacol. 1984 Oct 15;33(20):3283-7. doi: 10.1016/0006-2952(84)90091-1.
The effect of dietary fat upon ethanol metabolism was studied in rats. Wistar strain male rats were divided into four groups according to diet, namely alcohol-high fat, alcohol-low fat, control-high fat, and control-low fat. After 4 weeks of feeding, blood ethanol levels following an intraperitoneal injection of 0.2 g ethanol/100 g of body weight were measured. The disappearance rate of blood ethanol was faster and the metabolic rate of ethanol was significantly greater in the alcohol-high fat group compared to the alcohol-low fat or non-alcoholic groups. Microsomal enzymes, such as the microsomal ethanol-oxidizing system, aniline hydroxylase, and glucose-6-phosphatase, were significantly higher in the alcohol-high fat group than in the alcohol-low fat or non-alcoholic groups. The ethanol uptake rate of the isolated perfused liver was increased significantly in the alcoholic groups. In the alcoholic rats, the high fat group showed significantly higher uptake than the low fat group. Although the ethanol uptake rate after 4-methylpyrazole treatment was not significantly different among the four groups, its fraction of the total ethanol uptake was increased significantly in the alcohol-high fat group. These results suggest that high fat diets accelerate ethanol metabolism through the microsomal ethanol-oxidizing system.
在大鼠中研究了膳食脂肪对乙醇代谢的影响。将Wistar品系雄性大鼠根据饮食分为四组，即酒精-高脂肪组、酒精-低脂肪组、对照-高脂肪组和对照-低脂肪组。喂养4周后，测量腹腔注射0.2 g乙醇/100 g体重后的血乙醇水平。与酒精-低脂肪组或非酒精组相比，酒精-高脂肪组血乙醇的消失速率更快，乙醇代谢率显著更高。微粒体酶，如微粒体乙醇氧化系统、苯胺羟化酶和葡萄糖-6-磷酸酶，在酒精-高脂肪组中显著高于酒精-低脂肪组或非酒精组。分离的灌注肝脏的乙醇摄取率在酒精组中显著增加。在酒精性大鼠中，高脂肪组的摄取显著高于低脂肪组。尽管4-甲基吡唑处理后的乙醇摄取率在四组之间无显著差异，但其在总乙醇摄取中的比例在酒精-高脂肪组中显著增加。这些结果表明，高脂肪饮食通过微粒体乙醇氧化系统加速乙醇代谢。
