性别和口服避孕药类固醇作为药物葡萄糖醛酸化的决定因素：对氯贝酸消除的影响。
Gender and oral contraceptive steroids as determinants of drug glucuronidation: effects on clofibric acid elimination.
作者信息
Miners J O, Robson R A, Birkett D J
出版信息
Br J Clin Pharmacol. 1984 Aug;18(2):240-3. doi: 10.1111/j.1365-2125.1984.tb02461.x.
Abstract
The disposition of clofibric acid, a drug metabolised largely by glucuronidation, was studied in eight males, eight females and eight females receiving oral contraceptive steroids (OCS). Clofibric acid plasma clearance was not significantly different in males compared to the control female group but was 48% greater (P less than 0.01) in women receiving OCS compared to non-pill using females. This difference was due to an alteration in clofibric acid metabolic clearance as there were no differences between the groups in clofibric acid free fraction. Along with previous data the results suggest that induction of drug glucuronidation by OCS may be of clinical importance, although any sex-related differences are unlikely to be of clinical significance.
摘要
在8名男性、8名女性以及8名服用口服避孕药类固醇（OCS）的女性中研究了氯贝酸（一种主要通过葡萄糖醛酸化代谢的药物）的处置情况。与对照女性组相比，男性的氯贝酸血浆清除率无显著差异，但与未服用避孕药的女性相比，服用OCS的女性的氯贝酸血浆清除率高48%（P<0.01）。这种差异是由于氯贝酸代谢清除率的改变，因为各组之间氯贝酸的游离分数没有差异。结合先前的数据，结果表明OCS诱导药物葡萄糖醛酸化可能具有临床重要性，尽管任何性别相关差异不太可能具有临床意义。
相似文献
1
Gender and oral contraceptive steroids as determinants of drug glucuronidation: effects on clofibric acid elimination.性别和口服避孕药类固醇作为药物葡萄糖醛酸化的决定因素：对氯贝酸消除的影响。
Br J Clin Pharmacol. 1984 Aug;18(2):240-3. doi: 10.1111/j.1365-2125.1984.tb02461.x.
2
Influence of sex and oral contraceptive steroids on paracetamol metabolism.性别及口服避孕药类固醇对扑热息痛代谢的影响。
Br J Clin Pharmacol. 1983 Nov;16(5):503-9. doi: 10.1111/j.1365-2125.1983.tb02207.x.
3
Oral contraceptives stimulate the excretion of clofibric acid glucuronide in women and female rats.口服避孕药会刺激女性和雌性大鼠排出氯贝酸葡糖苷酸。
Gen Pharmacol. 1991;22(2):393-7. doi: 10.1016/0306-3623(91)90470-q.
4
Influence of gender and oral contraceptive steroids on the metabolism of salicylic acid and acetylsalicylic acid.性别和口服避孕药类固醇对水杨酸和乙酰水杨酸代谢的影响。
Br J Clin Pharmacol. 1986 Aug;22(2):135-42. doi: 10.1111/j.1365-2125.1986.tb05240.x.
5
Effects of oral contraceptive steroids on acetaminophen metabolism and elimination.口服避孕类固醇对乙酰氨基酚代谢和消除的影响。
Clin Pharmacol Ther. 1983 Jul;34(1):48-53. doi: 10.1038/clpt.1983.127.
6
Differential effects of oral contraceptive steroids on the metabolism of benzodiazepines.口服避孕药类固醇对苯二氮䓬类药物代谢的不同影响。
Hepatology. 1983 Mar-Apr;3(2):248-53. doi: 10.1002/hep.1840030219.
7
Lorazepam and oxazepam kinetics in women on low-dose oral contraceptives.低剂量口服避孕药对女性劳拉西泮和奥沙西泮药代动力学的影响
Clin Pharmacol Ther. 1983 May;33(5):628-32. doi: 10.1038/clpt.1983.85.
8
Disposition of chlordiazepoxide: sex differences and effects of oral contraceptives.氯氮卓的处置：性别差异及口服避孕药的影响
Clin Pharmacol Ther. 1979 Jun;25(6):826-31. doi: 10.1002/cpt1979256826.
9
Effect of chronic oral contraceptive steroids on theophylline disposition.慢性口服避孕药类固醇对茶碱处置的影响。
Eur J Clin Pharmacol. 1982;23(2):129-34. doi: 10.1007/BF00545966.
10
Imipramine disposition in users of oral contraceptive steroids.口服避孕药类固醇使用者体内丙咪嗪的处置情况。
Clin Pharmacol Ther. 1984 Jun;35(6):792-7. doi: 10.1038/clpt.1984.114.
引用本文的文献
1
Consensus Statement on the Use of Oral Contraceptive Pills in Polycystic Ovarian Syndrome Women in India.印度多囊卵巢综合征女性口服避孕药使用的共识声明。
J Hum Reprod Sci. 2018 Apr-Jun;11(2):96-118. doi: 10.4103/jhrs.JHRS_72_18.
2
Challenges and Opportunities with Predicting in Vivo Phase II Metabolism via Glucuronidation from in Vitro Data.通过体外数据预测体内II期葡萄糖醛酸化代谢的挑战与机遇
Curr Pharmacol Rep. 2016 Dec;2(6):326-338. doi: 10.1007/s40495-016-0076-8. Epub 2016 Nov 8.
3
Sex differences in the pharmacokinetics of antidepressants: influence of female sex hormones and oral contraceptives.抗抑郁药药代动力学的性别差异：女性性激素和口服避孕药的影响。
Clin Pharmacokinet. 2014 Jun;53(6):509-19. doi: 10.1007/s40262-014-0145-2.
4
Pharmacokinetic drug interactions involving 17alpha-ethinylestradiol: a new look at an old drug.涉及17α-乙炔雌二醇的药代动力学药物相互作用：对一种老药的新审视。
Clin Pharmacokinet. 2007;46(2):133-57. doi: 10.2165/00003088-200746020-00003.
5
The influence of sex on pharmacokinetics.性别对药代动力学的影响。
Clin Pharmacokinet. 2003;42(2):107-21. doi: 10.2165/00003088-200342020-00001.
6
In vitro-in vivo correlations for drugs eliminated by glucuronidation: investigations with the model substrate zidovudine.通过葡萄糖醛酸化消除的药物的体外-体内相关性：以模型底物齐多夫定进行的研究。
Br J Clin Pharmacol. 2002 Nov;54(5):493-503. doi: 10.1046/j.1365-2125.2002.01669.x.
7
Alteration in sexually dimorphic testosterone biotransformation profiles as a biomarker of chemically induced androgen disruption in mice.性二态性睾酮生物转化谱的改变作为小鼠化学诱导雄激素干扰的生物标志物。
Environ Health Perspect. 1999 May;107(5):377-84. doi: 10.1289/ehp.99107377.
8
Genetic and environmental factors associated with variation of human xenobiotic glucuronidation and sulfation.与人类外源性物质葡萄糖醛酸化和硫酸化变异相关的遗传和环境因素。
Environ Health Perspect. 1997 Jun;105 Suppl 4(Suppl 4):739-47. doi: 10.1289/ehp.97105s4739.
9
Gender differences in pharmacokinetics.药物代谢动力学中的性别差异。
Eur J Drug Metab Pharmacokinet. 1996 Apr-Jun;21(2):123-8. doi: 10.1007/BF03190260.
10
Gender effects in pharmacokinetics and pharmacodynamics.药代动力学和药效学中的性别效应。
Drugs. 1995 Aug;50(2):222-39. doi: 10.2165/00003495-199550020-00003.
本文引用的文献
1
Probenecid-clofibrate interaction.
Clin Pharmacol Ther. 1981 Mar;29(3):351-8. doi: 10.1038/clpt.1981.48.
2
Environmental factors affecting paracetamol metabolism in London factory and office workers.影响伦敦工厂和办公室工作人员对乙酰氨基酚代谢的环境因素。
Br J Clin Pharmacol. 1980 Jul;10(1):67-74. doi: 10.1111/j.1365-2125.1980.tb00503.x.
3
The simultaneous analysis of clofibric acid and probenecid and the direct analysis of clofibric acid glucuronide by high-performance liquid chromatography.
J Chromatogr. 1981 Apr 10;223(1):147-54. doi: 10.1016/s0378-4347(00)80077-8.
4
Acetaminophen kinetics in the elderly.对乙酰氨基酚在老年人中的动力学
Clin Pharmacol Ther. 1982 Feb;31(2):151-6. doi: 10.1038/clpt.1982.24.
5
Increased metabolic clearance of acetaminophen with oral contraceptive use.
Obstet Gynecol. 1982 Sep;60(3):338-41.
6
Effects of oral contraceptive steroids on acetaminophen metabolism and elimination.口服避孕类固醇对乙酰氨基酚代谢和消除的影响。
Clin Pharmacol Ther. 1983 Jul;34(1):48-53. doi: 10.1038/clpt.1983.127.
7
Influence of sex and oral contraceptive steroids on paracetamol metabolism.性别及口服避孕药类固醇对扑热息痛代谢的影响。
Br J Clin Pharmacol. 1983 Nov;16(5):503-9. doi: 10.1111/j.1365-2125.1983.tb02207.x.
8
UDP-glucuronosyltransferase activities. Guidelines for consistent interim terminology and assay conditions.UDP-葡糖醛酸基转移酶活性。一致的临时术语和测定条件指南。
Biochem Pharmacol. 1983 Mar 15;32(6):953-5. doi: 10.1016/0006-2952(83)90610-x.
9
Lorazepam and oxazepam kinetics in women on low-dose oral contraceptives.低剂量口服避孕药对女性劳拉西泮和奥沙西泮药代动力学的影响
Clin Pharmacol Ther. 1983 May;33(5):628-32. doi: 10.1038/clpt.1983.85.
10
Lack of effect of cholestyramine on the pharmacokinetics of clofibrate in man.
Eur J Clin Invest. 1975 Apr;5(2):177-85. doi: 10.1111/j.1365-2362.1975.tb00444.x.
Zotero 插件