性别和口服避孕药类固醇作为药物葡萄糖醛酸化的决定因素：对氯贝酸消除的影响。
Gender and oral contraceptive steroids as determinants of drug glucuronidation: effects on clofibric acid elimination.
作者信息
Miners J O, Robson R A, Birkett D J
出版信息
Br J Clin Pharmacol. 1984 Aug;18(2):240-3. doi: 10.1111/j.1365-2125.1984.tb02461.x.
Abstract
The disposition of clofibric acid, a drug metabolised largely by glucuronidation, was studied in eight males, eight females and eight females receiving oral contraceptive steroids (OCS). Clofibric acid plasma clearance was not significantly different in males compared to the control female group but was 48% greater (P less than 0.01) in women receiving OCS compared to non-pill using females. This difference was due to an alteration in clofibric acid metabolic clearance as there were no differences between the groups in clofibric acid free fraction. Along with previous data the results suggest that induction of drug glucuronidation by OCS may be of clinical importance, although any sex-related differences are unlikely to be of clinical significance.
摘要
在8名男性、8名女性以及8名服用口服避孕药类固醇（OCS）的女性中研究了氯贝酸（一种主要通过葡萄糖醛酸化代谢的药物）的处置情况。与对照女性组相比，男性的氯贝酸血浆清除率无显著差异，但与未服用避孕药的女性相比，服用OCS的女性的氯贝酸血浆清除率高48%（P<0.01）。这种差异是由于氯贝酸代谢清除率的改变，因为各组之间氯贝酸的游离分数没有差异。结合先前的数据，结果表明OCS诱导药物葡萄糖醛酸化可能具有临床重要性，尽管任何性别相关差异不太可能具有临床意义。
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