性别及口服避孕药类固醇对扑热息痛代谢的影响。
Influence of sex and oral contraceptive steroids on paracetamol metabolism.
作者信息
Miners J O, Attwood J, Birkett D J
出版信息
Br J Clin Pharmacol. 1983 Nov;16(5):503-9. doi: 10.1111/j.1365-2125.1983.tb02207.x.
Abstract
Paracetamol metabolism was investigated in eight healthy males, eight healthy females and eight healthy females receiving oral contraceptive steroids (OCS). Paracetamol clearance was 22% greater in males compared to the control female group. This difference was entirely due to increased activity of the glucuronidation pathway in males, there being no sex-related differences in the sulphation or oxidative metabolism of paracetamol. Paracetamol clearance in females using OCS was 49% greater than in the control females. Glucuronidation and oxidative metabolism were both induced in OCS users (by 78% and 36% respectively) but sulphation was not altered. Although sex-related differences in paracetamol metabolism are unlikely to be of clinical importance, induction of paracetamol metabolism by OCS may have clinical and toxicological consequences.
摘要
对8名健康男性、8名健康女性以及8名正在服用口服避孕药类固醇（OCS）的健康女性进行了扑热息痛代谢研究。与对照女性组相比，男性的扑热息痛清除率高22%。这种差异完全是由于男性体内葡萄糖醛酸化途径活性增加所致，扑热息痛的硫酸化或氧化代谢不存在性别相关差异。使用OCS的女性的扑热息痛清除率比对照女性高49%。OCS使用者的葡萄糖醛酸化和氧化代谢均被诱导（分别提高了78%和36%），但硫酸化未改变。尽管扑热息痛代谢的性别相关差异可能不具有临床重要性，但OCS对扑热息痛代谢的诱导可能会产生临床和毒理学后果。
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