哌唑嗪和丙二醇对哮喘患者甲氧明诱发支气管收缩的作用。
The action of prazosin and propylene glycol on methoxamine-induced bronchoconstriction in asthmatic subjects.
作者信息
Black J L, Salome C, Yan K, Shaw J
出版信息
Br J Clin Pharmacol. 1984 Sep;18(3):349-53. doi: 10.1111/j.1365-2125.1984.tb02475.x.
Abstract
The effect of 1 mg inhaled prazosin on bronchoconstriction induced by methoxamine was investigated in seven asthmatic subjects. Prazosin caused significant inhibition of the methoxamine-induced bronchoconstriction in six of the seven patients. These findings suggest that methoxamine produces bronchoconstriction in asthmatic subjects via stimulation of alpha-adrenoceptors. In previous studies propylene glycol has been used as a vehicle for delivery of prazosin. This substance was found to cause significant inhibition of methoxamine effects and to shift the dose response curve to histamine to the right in four of seven patients.
摘要
在七名哮喘患者中研究了吸入1毫克哌唑嗪对甲氧明诱发的支气管收缩的影响。七名患者中有六名，哌唑嗪对甲氧明诱发的支气管收缩有显著抑制作用。这些发现表明，甲氧明通过刺激α-肾上腺素能受体在哮喘患者中引起支气管收缩。在先前的研究中，丙二醇一直被用作哌唑嗪的给药载体。发现该物质在七名患者中有四名会显著抑制甲氧明的作用，并使组胺的剂量反应曲线右移。
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