α-肾上腺素能受体刺激对正常人和哮喘患者气道的影响。

The effect of alpha-adrenoreceptor stimulation on the airways of normal and asthmatic man.

Snashall P D, Boother F A, Sterling G M

Clin Sci Mol Med. 1978 Mar;54(3):283-9. doi: 10.1042/cs0540283.

Abstract

The bronchial response to alpha-adrenoreceptor stimulation has been investigated in normal and asthmatic subjects with a specific alpha-receptor agonist, methoxamine hydrochloride, after atropine and beta-adrenergic blockade. 2. No significant changes in forced expiratory volume in 1 s (FEV1.0) were seen in normal subjects. 3. Methoxamine inhalation caused mild symptomatic wheezing and significant falls in FEV1.0 in asthmatic subjects. No change in FEV1.0 occurred after inhalation of distilled water as control. 4. It therefore appears that methoxamine causes bronchoconstriction in asthmatic subjects through its alpha-adrenergic-stimulating properties, since we were not able to detect any beta-receptor-blocking activity of methoxamine on the airways.

摘要

在阿托品和β-肾上腺素能阻滞剂作用后，使用特异性α受体激动剂盐酸美索明，对正常人和哮喘患者的支气管对α-肾上腺素能受体刺激的反应进行了研究。2. 正常受试者1秒用力呼气量（FEV1.0）未见明显变化。3. 吸入美索明可导致哮喘患者出现轻度症状性喘息，FEV1.0显著下降。吸入蒸馏水作为对照后，FEV1.0未发生变化。4. 因此，似乎美索明通过其α-肾上腺素能刺激特性导致哮喘患者支气管收缩，因为我们未能检测到美索明对气道的任何β受体阻断活性。