Nagai K, Frohman L A
Diabetes. 1978 May;27(5):577-82. doi: 10.2337/diab.27.5.577.
The hyperglycemic and hyperglucagonemic effects of systemically administered neurotensin in rats were investigated to explore the possibility that they are mediated by histamine and to determine whether neurotensin might have a role in the mediation of the responses to central nervous system glucopenia. The hyperglycemic response to neurotensin was partially blocked by the histamine H-1 receptor blockers, diphenhydramine and promethazine, and by the H-2 receptor blocker, cimetidine. The hyperglucagonemic response was completely blocked by diphenhydramine and promethazine and only partially blocked by cimetidine. The effects of histamine on glucose, glucagon, and insulin secretion were similar to those of neurotensin, and the inhibitory effects of both H-1 and H-2 blockers were comparable. The stimulatory effect of histamine on insulin secretion observed after adrenal autotransplantation was also similar to that previously reported for neurotensin. Neither antineurotensin serum nor diphenhydramine, however, was effective in blocking the hyperglycemic and hyperglucagonemic responses to the central administration of 2-deoxyglucose. The results are consistent with a histamine mediation of the effects of exogenously administered neurotensin but do not support a proposed role for neurotensin or histamine in the mediation of the hyperglycemic and hyperglucagonemic responses to central glucopenia.
研究了全身给予神经降压素对大鼠的高血糖和高胰高血糖素作用，以探讨这些作用是否由组胺介导，并确定神经降压素在介导对中枢神经系统低血糖的反应中是否可能起作用。组胺H-1受体阻滞剂苯海拉明和异丙嗪以及H-2受体阻滞剂西咪替丁可部分阻断对神经降压素的高血糖反应。苯海拉明和异丙嗪可完全阻断高胰高血糖素反应，而西咪替丁仅能部分阻断。组胺对葡萄糖、胰高血糖素和胰岛素分泌的作用与神经降压素相似，H-1和H-2阻滞剂的抑制作用相当。肾上腺自体移植后观察到的组胺对胰岛素分泌的刺激作用也与先前报道的神经降压素相似。然而，抗神经降压素血清和苯海拉明均不能有效阻断对中枢给予2-脱氧葡萄糖的高血糖和高胰高血糖素反应。这些结果与外源性给予神经降压素的作用由组胺介导一致，但不支持神经降压素或组胺在介导对中枢低血糖的高血糖和高胰高血糖素反应中起作用的观点。
