Nagai N, Nagai K, Takezawa K, Chun S J, Nakagawa H
Division of Protein Metabolism, Osaka University, Japan.
Neurosci Lett. 1995 May 12;190(3):187-90. doi: 10.1016/0304-3940(95)11536-6.
Vasopressin (VP) is a peptide consisting of 9 amino acids which acts as a neurotransmitter or neuromodulator in the central nervous system. Neurons containing VP project to some nuclei in the hypothalamus that have a role in energy metabolism. To clarify the possible role of VP on glucose metabolism in the brain, we examined the effect of intracranial injection of VP on the hyperglycemia induced by 2-deoxy-D-glucose (2DG) and obtained the following results. The hyperglycemic and hyperglucagonemic responses induced by 2DG were significantly suppressed and enhanced by co-injections of VP and a VP-antagonist with 2DG, respectively. However, co-injections of either VP or a VP-antagonist with 2DG had no effect on the change in plasma insulin concentration. These findings suggest that central VP plays a suppressive role in the hyperglycemic and hyperglucagonemic responses to 2DG.
血管加压素（VP）是一种由9个氨基酸组成的肽，在中枢神经系统中作为神经递质或神经调节剂发挥作用。含有VP的神经元投射到下丘脑中一些在能量代谢中起作用的核团。为了阐明VP对大脑葡萄糖代谢的可能作用，我们研究了颅内注射VP对2-脱氧-D-葡萄糖（2DG）诱导的高血糖的影响，并得到了以下结果。分别与2DG共同注射VP和VP拮抗剂可显著抑制和增强2DG诱导的高血糖和高胰高血糖素反应。然而，VP或VP拮抗剂与2DG共同注射对血浆胰岛素浓度的变化没有影响。这些发现表明，中枢VP在对2DG的高血糖和高胰高血糖素反应中起抑制作用。
