氧烯洛尔的胎盘转运、新生儿血浆浓度及进入母乳的情况。
Oxprenolol placental transfer, plasma concentrations in newborns and passage into breast milk.
作者信息
Sioufi A, Hillion D, Lumbroso P, Wainer R, Olivier-Martin M, Schoeller J P, Colussi D, Leroux F, Mangoni P
出版信息
Br J Clin Pharmacol. 1984 Sep;18(3):453-6. doi: 10.1111/j.1365-2125.1984.tb02489.x.
Thirty-two pregnant hypertensive patients were treated with oxprenolol administered in combination with dihydralazine as Trasipressol tablets. Before delivery, oxprenolol was demonstrable in the maternal plasma and the amniotic fluid. The free fraction of oxprenolol in the maternal serum (15% +/- 7.8; mean +/- s.d.; n = 25) was similar to that in normal serum. At the end of delivery, oxprenolol was found in both the maternal and umbilical plasma in most cases. Measurable, but low oxprenolol concentrations were present in the newborn plasma. After delivery, oxprenolol was demonstrable in the maternal plasma and breast milk. An infant weighing 3 kg and consuming 500 ml of breast milk per day would receive a maximum dose 60 times less than the normal daily dose for a hypertensive adult (4 mg/kg).
32例妊娠高血压患者接受了氧烯洛尔与双肼屈嗪联合制成的Trasipressol片剂治疗。分娩前，在母体血浆和羊水中可检测到氧烯洛尔。母体血清中氧烯洛尔的游离分数（15%±7.8；均值±标准差；n = 25）与正常血清中的相似。分娩结束时，多数情况下在母体和脐血浆中均发现有氧烯洛尔。新生儿血浆中存在可测量但浓度较低的氧烯洛尔。分娩后，在母体血浆和母乳中可检测到氧烯洛尔。一名体重3kg、每天摄入500ml母乳的婴儿所接受的最大剂量比高血压成人的正常日剂量（4mg/kg）少60倍。
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