Dubois M, Delapierre D, Chanteux L, Demonty J, Lambotte R, Kramp R, Dresse A
J Clin Pharmacol. 1981 Nov-Dec;21(11):477-83. doi: 10.1002/j.1552-4604.1981.tb05653.x.
Cefoxitin is a new semisynthetic cephamycin derivative with broad bactericidal activities. In order to determine the extent of the transplacental transfer of cefoxitin, 35 pregnant women received 1 Gm cefoxitin intramuscularly 15 to 180 minutes before normal or Caesarean delivery. Cefoxitin was measured microbiologically in maternal blood (multiple-time samples), umbilical blood (one-time sample), and amniotic fluid in the cases of Caesarean sections. The mammary excretion of cefoxitin injected at the same dose was investigated by measuring cefoxitin in the milk of 16 nursing mothers. In the maternal blood, a peak plasma level of approximately 25 microgram/ml was reached 30 minutes after the 1-Gm intramuscular injection. A clear-cut passage of cefoxitin in the umbilical cord blood was demonstrated. In the fetal blood, a peak level of 15 microgram/ml was obtained 45 minutes after the injection. No cefoxitin was detectable in any of the milk samples from 30 minutes to 24 hours after the 1-Gm intramuscular injection.
头孢西丁是一种新型半合成头孢霉素衍生物，具有广泛的杀菌活性。为了确定头孢西丁经胎盘转运的程度，35名孕妇在正常分娩或剖宫产术前15至180分钟接受了1克头孢西丁的肌肉注射。剖宫产病例中，对母体血液（多次采样）、脐血（单次采样）和羊水进行了头孢西丁的微生物学测定。通过测定16名哺乳期母亲乳汁中的头孢西丁，研究了相同剂量注射后头孢西丁的乳腺排泄情况。在母体血液中，1克肌肉注射后30分钟达到约25微克/毫升的血浆峰值水平。脐血中证实有明显的头孢西丁通过。在胎儿血液中，注射后45分钟达到15微克/毫升的峰值水平。1克肌肉注射后30分钟至24小时的任何乳汁样本中均未检测到头孢西丁。
