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1
Anti-hypertensive therapy with propranolol during pregnancy and lactation.孕期及哺乳期使用普萘洛尔进行抗高血压治疗。
Postgrad Med J. 1981 Jul;57(669):427-30. doi: 10.1136/pgmj.57.669.427.
2
Levels of the beta-blockers atenolol and propranolol in the breast milk of women treated for hypertension in pregnancy.孕期接受高血压治疗的女性母乳中β受体阻滞剂阿替洛尔和普萘洛尔的含量。
Biopharm Drug Dispos. 1983 Jul-Sep;4(3):299-301. doi: 10.1002/bdd.2510040310.
3
Letter: Propranolol therapy during pregnancy and lactation.信函:孕期及哺乳期的普萘洛尔治疗
Am J Cardiol. 1976 Feb;37(2):325. doi: 10.1016/0002-9149(76)90331-3.
4
Management of hypertension during lactation.哺乳期高血压的管理。
Hypertension. 1984 May-Jun;6(3):297-300. doi: 10.1161/01.hyp.6.3.297.
5
Propranolol and hydrallazine in the management of essential hypertension in pregnancy.普萘洛尔与肼苯哒嗪用于妊娠期原发性高血压的治疗
Br J Obstet Gynaecol. 1980 Feb;87(2):110-4. doi: 10.1111/j.1471-0528.1980.tb04502.x.
6
Transplacental passage and breast milk concentrations of hydralazine.肼屈嗪的经胎盘转运及母乳中的浓度。
Eur J Clin Pharmacol. 1982;21(5):417-9. doi: 10.1007/BF00542329.
7
The possible adverse effect of propranolol on the fetus in pregnancies complicated by severe hypertension.普萘洛尔对合并严重高血压的妊娠中胎儿可能产生的不良影响。
Br J Obstet Gynaecol. 1978 Sep;85(9):678-83. doi: 10.1111/j.1471-0528.1978.tb14946.x.
8
Propranolol therapy during pregnancy and lactation.孕期及哺乳期的普萘洛尔治疗。
Am J Cardiol. 1973 Aug;32(2):247.
9
[Propranolol in treatment of hypertension in pregnancy].[普萘洛尔治疗妊娠期高血压]
Ugeskr Laeger. 1979 Dec 3;141(49):3372-4.
10
[Experiences with propranolol (Obsidan25) in hypertension therapy in pregnancy].[心得安(心得静25)用于妊娠高血压治疗的经验]
Pharmazie. 1985 Sep;40(9):645-7.

引用本文的文献

1
Beta-blockers and breastfeeding: a real-life prospective study.β受体阻滞剂与母乳喂养:一项真实世界的前瞻性研究。
Eur J Clin Pharmacol. 2024 Dec;80(12):1937-1943. doi: 10.1007/s00228-024-03753-y. Epub 2024 Sep 11.

本文引用的文献

1
Effect of 1-epinephrine infusion on uterine contractility and cardiovascular system.1-肾上腺素输注对子宫收缩力和心血管系统的影响。
Am J Obstet Gynecol. 1962 Aug 1;84:297-306. doi: 10.1016/0002-9378(62)90126-6.
2
Effects of adrenergic blocking agents and catecholamines in human pregnancy.肾上腺素能阻滞剂和儿茶酚胺在人类妊娠中的作用。
Am J Obstet Gynecol. 1968 Sep 15;102(2):226-35. doi: 10.1016/0002-9378(68)90323-2.
3
The effect of adrenergic receptor blocking drugs on the human uterus.肾上腺素能受体阻断药物对人体子宫的作用。
J Obstet Gynaecol Br Commonw. 1968 Feb;75(2):189-98. doi: 10.1111/j.1471-0528.1968.tb02031.x.
4
Repeated cardioversion during pregnancy. Treatment of refractory paroxysmal atrial tachycardia during 3 successive pregnancies.孕期反复进行心脏复律。连续3次妊娠期间难治性阵发性房性心动过速的治疗。
Am J Cardiol. 1971 Apr;27(4):445-6. doi: 10.1016/0002-9149(71)90443-7.
5
The effect of propranolol on the onset of breathing at birth.普萘洛尔对出生时呼吸开始的影响。
Br J Anaesth. 1969 Sep;41(9):792.
6
Propranolol therapy throughout pregnancy: a case report.孕期全程使用普萘洛尔治疗:一例报告
Anesth Analg. 1974 Mar-Apr;53(2):214.
7
Propranolol therapy during pregnancy and lactation.孕期及哺乳期的普萘洛尔治疗。
Am J Cardiol. 1973 Aug;32(2):247.
8
Adrenergic blockade. A new approach to hyperthyroidism during pregnancy.肾上腺素能阻滞剂。孕期甲状腺功能亢进症的一种新疗法。
Obstet Gynecol. 1974 Aug;44(2):181-6.
9
Letter: Excretion of propranolol in human breast milk.信件:普萘洛尔在人母乳中的排泄。
Acta Pharmacol Toxicol (Copenh). 1974 Mar;34(3):222-4.
10
Management of pregnancy complicated by hypertrophic obstructive cardiomyopathy.肥厚型梗阻性心肌病合并妊娠的管理
Br Med J. 1968 Nov 2;4(5626):281-4. doi: 10.1136/bmj.4.5626.281.

孕期及哺乳期使用普萘洛尔进行抗高血压治疗。

Anti-hypertensive therapy with propranolol during pregnancy and lactation.

作者信息

Taylor E A, Turner P

出版信息

Postgrad Med J. 1981 Jul;57(669):427-30. doi: 10.1136/pgmj.57.669.427.

DOI:10.1136/pgmj.57.669.427
PMID:7312737
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2424946/
Abstract

A hypertensive women was treated throughout pregnancy with propranolol 40 mg daily without complication. At delivery the umbilical cord plasma concentration was similar to that in the maternal venous plasma. Milk:plasma ratios were less than 1, although a higher ratio would be predicted. Estimated daily intake of propranolol in breast milk by the infant was about 3 micrograms. There appears to be no reason to advise women receiving propranolol to avoid breast feeding.

摘要

一位高血压女性在整个孕期每天服用40毫克普萘洛尔,未出现并发症。分娩时,脐带血浆浓度与母体静脉血浆浓度相似。母乳与血浆的比值小于1,尽管预计会有更高的比值。婴儿通过母乳摄入普萘洛尔的估计每日量约为3微克。似乎没有理由建议服用普萘洛尔的女性避免母乳喂养。