用于结肠痉挛综合征的缓释薄荷油胶囊（Colpermin）：一项药代动力学研究。
Delayed release peppermint oil capsules (Colpermin) for the spastic colon syndrome: a pharmacokinetic study.
作者信息
Somerville K W, Richmond C R, Bell G D
出版信息
Br J Clin Pharmacol. 1984 Oct;18(4):638-40. doi: 10.1111/j.1365-2125.1984.tb02519.x.
Abstract
Excretion of menthol (as glucuronide) from orally ingested peppermint oil contained in Colpermin was compared with oil contained in two soft gelatine capsules. Total 24 h urinary excretion of menthol was similar in the two formulations in healthy volunteers, but peak menthol excretion levels were lower and excretion delayed with Colpermin. Menthol excretion was reduced in ileostomy patients who took Colpermin and moderate amounts of unmetabolised menthol were recovered from the ileostomy effluent. This is consistent with Colpermin being a delayed-release form of peppermint oil.
摘要
将Colpermin中口服摄入的薄荷油（以葡糖醛酸苷形式）的薄荷醇排泄情况与两种软胶囊中的油进行了比较。在健康志愿者中，两种制剂中薄荷醇的24小时总尿排泄量相似，但Colpermin的薄荷醇排泄峰值水平较低且排泄延迟。服用Colpermin的回肠造口术患者的薄荷醇排泄减少，并且从回肠造口术流出物中回收了适量未代谢的薄荷醇。这与Colpermin是薄荷油的缓释形式一致。
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