具有高血糖特性的人生长激素合成片段：第44至77位氨基酸残基

Synthetic fragment of human growth hormone with hyperglycemic properties: residues 44-77.

作者信息

Lostroh A J, Krahl M E

出版信息

Diabetes. 1978 May;27(5):597-8. doi: 10.2337/diab.27.5.597.

DOI:10.2337/diab.27.5.597

Abstract

Peptides homologous to Cys53 44-77 and Cys53 52-77 of the human growth hormone molecule were prepared by solid-phase synthesis and tested by our acute glucose tolerance test in ob/ob mice. Peptide 44-77, as either the Acm-Cys53 or Cam-Cys53 derivative, adversely affects glucose tolerance at doses of 100 to 150 nmol. Peptide 52-77 is nonhyperglycemic. Other diabetogenic properties are being tested.

摘要

通过固相合成制备了与人生长激素分子的Cys53 44 - 77和Cys53 52 - 77同源的肽，并在ob/ob小鼠中通过我们的急性葡萄糖耐量试验进行了测试。肽44 - 77，无论是Acm - Cys53还是Cam - Cys53衍生物，在100至150 nmol的剂量下都会对葡萄糖耐量产生不利影响。肽52 - 77不会引起高血糖。正在测试其他致糖尿病特性。