英国17个中心可手术直肠癌预后意义的临床病理特征（医学研究委员会试验的第三次报告，代表工作小组）
Clinico-pathological features of prognostic significance in operable rectal cancer in 17 centres in the U.K. (Third report of the M.R.C. Trial, on behalf of the Working Party).
出版信息
Br J Cancer. 1984 Oct;50(4):435-42. doi: 10.1038/bjc.1984.198.
Abstract
Clinico-pathological features of prognostic significance in rectal cancer are described in 824 patients who were treated at 17 centres in the Medical Research Council Trial of radiotherapy in operable cancer of the rectum. Among the pre-operative assessments the mobility of the tumour was the one most strongly related to prognosis. Other variables predictive of outcome were the number of involved quadrants of the rectum, the distance of the tumour from the anal verge and the age of the patient. Of assessments made at surgery or immediately after, the report of a curative operation and the Dukes' classification most closely related to prognosis. The information presented supports the idea that a pre-operative clinical staging system for rectal cancer would be feasible and useful.
摘要
在医学研究委员会开展的直肠癌可手术切除患者放疗试验中，17个中心对824例患者进行了治疗，描述了具有预后意义的临床病理特征。在术前评估中，肿瘤的活动度与预后的相关性最强。其他可预测预后的变量包括直肠受累象限的数量、肿瘤距肛缘的距离以及患者的年龄。在手术时或术后立即进行的评估中，根治性手术报告和 Dukes 分期与预后的关系最为密切。所提供的信息支持这样一种观点，即直肠癌术前临床分期系统是可行且有用的。
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