结直肠癌：临床和病理因素对生存的重要性
Colorectal carcinoma: importance of clinical and pathological factors in survival.
作者信息
Deans G T, Patterson C C, Parks T G, Spence R A, Heatley M, Moorehead R J, Rowlands B J
机构信息
Department of Surgery, Queen's University, Belfast.
出版信息
Ann R Coll Surg Engl. 1994 Jan;76(1):59-64.
A series of clinicopathological variables was assessed on 312 patients undergoing surgical resection for primary colorectal cancer. Although the presence of venous invasion was related to mortality (P = 0.02), classifying invasion into involvement of thick-walled or thin-walled veins did not produce a variable of prognostic value. Intestinal obstruction (P = 0.04) and the macroscopic appearance of the tumour (P = 0.04) were related to mortality from colorectal cancer, but not from all causes of death. Duke's stage, increasing patient age and poorly differentiated tumours were the variables which were individually most significantly related to poor prognosis (P < 0.001 for each analysis). Cox's regression analysis identified these three variables as independent predictors of outcome in colorectal cancer. This study confirms that Duke's stage, patient age and tumour differentiation are still the most important clinicopathological variables in colorectal cancer.
对312例接受原发性结直肠癌手术切除的患者评估了一系列临床病理变量。尽管静脉侵犯的存在与死亡率相关（P = 0.02），但将侵犯分类为厚壁或薄壁静脉受累并未产生具有预后价值的变量。肠梗阻（P = 0.04）和肿瘤的宏观表现（P = 0.04）与结直肠癌死亡率相关，但与所有死因无关。杜克分期、患者年龄增加和肿瘤分化差是分别与预后不良最显著相关的变量（每项分析P < 0.001）。Cox回归分析确定这三个变量为结直肠癌预后的独立预测因素。本研究证实，杜克分期、患者年龄和肿瘤分化仍然是结直肠癌最重要的临床病理变量。
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