McNamara D J
Biochim Biophys Acta. 1984 Oct 24;796(1):51-4. doi: 10.1016/0005-2760(84)90237-6.
Sterol balance measurements of whole body cholesterol synthesis were performed in guinea pigs to determine the relative quantitative importance of dietary cholesterol intake, endogenous cholesterol synthesis, fecal steroid excretion and net tissue accumulation in cholesterol homeostasis of a rapidly growing animal. Sterol inputs were from diet (33%) and endogenous synthesis (67%); sterol outputs, as fecal neutral and acidic steroids, accounted for 60% of the total input, the remainder being used for the demands of tissue growth. The data demonstrate that the measurement of total body cholesterol synthesis can be grossly underestimated in this rapidly growing animal if net tissue accumulation of cholesterol is not considered in the balance measurement.
在豚鼠身上进行了全身胆固醇合成的甾醇平衡测量，以确定饮食胆固醇摄入、内源性胆固醇合成、粪便类固醇排泄和净组织积累在快速生长动物胆固醇稳态中的相对定量重要性。甾醇输入来自饮食（33%）和内源性合成（67%）；作为粪便中性和酸性类固醇的甾醇输出占总输入的60%，其余用于满足组织生长的需求。数据表明，如果在平衡测量中不考虑胆固醇的净组织积累，那么在这种快速生长的动物中，全身胆固醇合成的测量可能会被严重低估。
