Babskiĭ A M, Shostakovskaia I V
Biull Eksp Biol Med. 1984 Sep;98(9):286-8.
Higher adrenalin sensitivity of mitochondrial processes in the small intestinal mucosa compared to that in liver mitochondria, was revealed under specially devised conditions of work with isolated mitochondria retaining their natural properties. Fifteen minutes after intraperitoneal injection of adrenalin into rats in a dose of 5 micrograms/100 bw an increase in Ca2+ capacity was seen only in intestinal mucosa mitochondria. The adrenalin-induced activation of oxidative phosphorylation was more remarkable in intestinal than in liver mitochondria at the initial stages of adrenalin action. The effect of adrenalin was completely reversed by the beta-blocker propranolol only in liver mitochondria. After 3 hours the adrenalin-induced activation of phosphorylation in the mitochondria ceases, whereas in the small intestinal mucosa it still persists.
在使用保留其自然特性的分离线粒体进行专门设计的工作条件下，发现小肠黏膜中线粒体过程的肾上腺素敏感性高于肝线粒体。以5微克/100体重的剂量给大鼠腹腔注射肾上腺素15分钟后，仅在小肠黏膜线粒体中观察到Ca2+容量增加。在肾上腺素作用的初始阶段，肾上腺素诱导的氧化磷酸化激活在小肠线粒体中比在肝线粒体中更显著。仅在肝线粒体中，β受体阻滞剂普萘洛尔可完全逆转肾上腺素的作用。3小时后，肾上腺素诱导的线粒体磷酸化激活停止，而在小肠黏膜中仍持续存在。
