Tutel'ian V A, Volgarev M N, Avren'eva L I, Sergeeva K V, Vasil'ev A V
Biull Eksp Biol Med. 1984 Sep;98(9):292-4.
Study of the interrelationship between immune responsiveness of the body and structural and functional status of the rat liver lysosomal apparatus under different alimentary conditions allowed one to establish that immune response during antigenic stimulation and complete fasting was considerably reduced. At the same time a dramatic rise in the total and non-sedimentable activities of some lysosomal hydrolases was recorded under the above conditions. The data obtained suggest that during acute malnutrition and antigenic stimulation, the rate of antibody synthesis is considerably decreased whereas activation of the lysosomal apparatus affected by both factors plays a compensatory role and is directed toward the most complete realization of the protective function of lysosomes.
在不同饮食条件下，对机体免疫反应性与大鼠肝脏溶酶体装置结构和功能状态之间的相互关系进行研究，结果表明，在抗原刺激和完全禁食期间，免疫反应显著降低。与此同时，在上述条件下，一些溶酶体水解酶的总活性和非沉淀活性急剧上升。所获得的数据表明，在急性营养不良和抗原刺激期间，抗体合成速率显著降低，而受这两种因素影响的溶酶体装置的激活发挥了补偿作用，旨在最充分地实现溶酶体的保护功能。
